International EARLY trial enrolling men and women ages 60 – 85 with normal memory function are encouraged to enroll by calling 855-568-7886
Tweet It:.@LouRuvoCenter is now seeking people ages 60-85 to enroll in the Alzheimer’s disease prevention trial, EARLY.
Cleveland Clinic Lou Ruvo Center for Brain Health is now seeking eligible participants to enroll in the multicenter Alzheimer’s disease prevention trial, EARLY.
The global research clinical trial measures the effectiveness and safety of the investigational drug JNJ-54861911 to determine its ability to prevent Alzheimer’s-associated memory loss in those at risk for developing the disease due to amyloid plaque buildup in the brain. Evidence of this buildup in people with normal memory function has been linked to an increased risk for the development of memory loss associated with Alzheimer’s disease later in life.
Men and women ages 60 to 85 with normal cognitive function and not currently being treated for memory issues are needed to complete the five-year, randomized, double-blind placebo-controlled study. In addition, those interested must be willing to take an investigational drug not yet approved by regulatory agencies and must have a reliable trial partner to accompany them to appointments. Participants are selected based on their risk of developing Alzheimer’s disease, which will be determined in the first part of the study by assessing the buildup of amyloid plaque in the brain.
“Having the technology to identify individuals at risk of Alzheimer’s disease and now with a medication that could potentially alter its course has opened up the possibility of preventing dementia,” said Charles Bernick, M.D., associate director of Cleveland Clinic Lou Ruvo Center for Brain Health. “This is an exciting new approach and I would encourage anyone within the eligible age group, particularly if Alzheimer’s runs in your family, to be proactive and consider participating in the EARLY study.”
Once participants are deemed eligible, they will continue to the second part of the study focusing on treatment. Throughout the treatment portion, participants will receive either an investigational drug or placebo to take via oral tablet for a period of four and a half years while participating in a variety of assessments such as questionnaires, interviews, blood tests and MRI scans during regularly scheduled visits at the Lou Ruvo Center for Brain Health. After the treatment period, participants will then complete the third and final portion of the study during a single follow-up appointment taking place one to four weeks after the last dose of medication.
For more information about the EARLY Study, including how to enroll, call 855-568-7886 or email firstname.lastname@example.org. For more information about Cleveland Clinic Lou Ruvo Center for Brain Health and other ongoing trials, visit CCF.org/BrainHealthTrials.
About Cleveland Clinic:
Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s best hospitals in its annual “America’s Best Hospitals” survey. More than 3,000 full-time salaried physicians and researchers and 11,000 nurses represent 120 medical specialties and subspecialties. The Cleveland Clinic health system includes a main campus near downtown Cleveland, eight community hospitals, more than 75 Northern Ohio outpatient locations, including 16 full-service Family Health Centers, Cleveland Clinic Florida, the Lou Ruvo Center for Brain Health in Las Vegas, Cleveland Clinic Canada, and Cleveland Clinic Abu Dhabi. In 2013, there were 5.5 million outpatient visits throughout the Cleveland Clinic health system and 157,000 hospital admissions. Patients came for treatment from every state and from more than 130 countries. Visit us at clevelandclinic.org. Follow us at twitter.com/ClevelandClinic.
About Cleveland Clinic Lou Ruvo Center for Brain Health:
Cleveland Clinic Lou Ruvo Center for Brain Health provides state-of-the-art care for cognitive disorders and for the family members of those who suffer from them. The physicians and staff at the Center for Brain Health continuously work towards the development of early diagnosis and the advancement of knowledge concerning mild cognitive disorders, which could one day delay or prevent their onset. Patients receive expert diagnosis and treatment at the Center for Brain Health, which offers a multidisciplinary patient-focused approach to diagnosis and treatment, promoting collaboration across all care providers, offering patients a complete continuum of care and infusing education and research into all that it does. The facility, designed by Frank Gehry, houses clinical space, a diagnostic center, neuroimaging rooms, physician offices, laboratories devoted to clinical research and the Keep Memory Alive Event Center. For more information, visit clevelandclinic.org/brainhealth.